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    • 专利摘要:
    BAG FOR A CIRCUIT OF A BIOLOGICAL LIQUID TREATMENT INSTALLATION. The invention relates to a bag consisting of a first duct (13J), a second duct (13K), the first section (13J1) of the first duct (13J) and the first section (13K1) of the second duct (13K) being opposite; a third duct (13L) connecting said respective first ends (13J2, 13K2) of the respective first sections (13J1, 13K1); a fourth duct (13M) connecting said second respective ends (13J3, 13K3) in said first respective sections (13J1, 13K1); a fifth duct (13N) connecting both said second end (13J3) of said first section (13J1) with said first end (13M1) of said fourth duct (13M), and said fifth duct (13N) connecting both, the said first end (13K2) with said second end (13L2) of said third duct (13L); said first duct (13J) and said second duct (13K) each being connected to a chromatography column connector (11M).
    公开号:BR112012030481B1
    申请号:R112012030481-0
    申请日:2011-06-20
    公开日:2020-12-29
    发明作者:Jean-Louis Weissenbach；Sébastien Cirou；Virginie Buisson
    申请人:Emd Millipore Corporation；
    IPC主号:
    专利说明:

    [0001] The invention relates to a bag for a device for a biological liquid treatment facility, and especially, but not exclusively, for the purification of a bio-pharmaceutical liquid, for obtaining products such as monoclonal antibodies , vaccines or recombinant proteins.
    [0002] The invention also relates to a device for a biological liquid treatment facility.
    [0003] It is known that in general, bio-pharmaceutical liquids are obtained by culture in a bio-reactor and that they must then be treated to obtain the required characteristics of purity, concentration, absence of viruses, etc.
    [0004] Purification is performed through a succession of treatments such as clarification to eliminate waste from the culture of the bio-reactor, and sometimes viral filtration followed by diafiltration and concentration by means of tangential flow filtration (TFF). There are other operations related to purification, such as chromatography (XMO).
    [0005] Purification treatments are essentially performed by filtration operations in a circuit that leads to a container to collect the treated liquid.
    [0006] A number of types of container containing liquids can be connected at the inlet of the circuit, such as the source container comprising the product to be treated, but also containers containing a cleaning liquid such as sodium hydroxide (NaOH ), a rinsing liquid such as pure water for injection or a buffer liquid such as saline. In addition to the container for collecting the treated liquid, several other containers for collecting the cleaning, rinsing or buffer liquid, or for collecting waste, can be connected at the outlet of the circuit.
    [0007] In a production context, liquid treatments can be performed in sequence, the collection container for the first treatment potentially becoming the source container for the next treatment, and so on, until the last treatment run.
    [0008] These treatments are conventionally carried out in specific installations comprising stainless steel tubes and other parts, such as tanks or filter housings, which require operations before and after the actual treatment, which are relatively expensive, especially operations for cleaning after the use.
    [0009] In recent years, these treatments have been carried out alternatively in installations where the components in contact with the liquid are single use components.
    [0010] Such single-use components have the advantage of avoiding cleaning operations, but to provide the required degree of safety, the implementation of an installation with such components requires selection, assembly and verification operations, which are relatively complex.
    [0011] This is especially the case when the number of tubes and other circuit components (connectors, valves, etc.) is high and / or when the operating pressure is high.
    [0012] According to the first aspect, the invention is directed to produce a bag that allows simple, economical and convenient implementation of treatments for biological liquid.
    [0013] For this purpose, the invention relates to a bag for a circuit of an installation for the treatment of a biological liquid by chromatography, comprising: - a number of connectors and a network for routing liquid between said connectors, said routing network being formed by a number of ducts; and - two flexible films connected with each other, said ducts being supplied between the two said flexible films;
    [0014] where a first duct is produced with a first section that has a first end and a second end that is an opposite end to the first end;
    [0015] where a second duct is produced with a first section that has a first end and a second end that is an opposite end to the first end, the first section of the first duct and the first section of the second duct being opposite;
    [0016] where a third duct has a first end and a second end which is an opposite end to the first end, the third duct of which connects said first ends of said first respective sections of said first duct and said second duct, respectively, through its first and second ends;
    [0017] where a fourth duct has a first end and a second end which is an opposite end to the first end, the fourth duct of which connects said respective second ends of said first respective sections of said first duct with said second duct, respectively, through its first end and its second end;
    [0018] where a fifth duct has a first end and a second end which is an end opposite the first end, said fifth duct connecting both, the second end of said first section with said first duct and said first end of said fourth duct through its first end, and said fifth duct connecting both said first end of said first section of said second duct and said second end of said third duct by its second end; and
    [0019] said first duct being connected with a chromatographic column connector by said first end of its first section, and said second duct being connected with a chromatographic column connector by said second end of its first section;
    [0020] where the bag is configured in such a way that the liquid to be treated passes into said chromatographic column through one of said first and second ducts, exits through the other of said first and second ducts, and the liquid to be treated will be able to avoid the said chromatographic column passing into the fifth duct.
    [0021] By virtue of the invention, the bag comprises an entry point at the intersection of the first, fourth and fifth ducts, an exit point at the intersection of the second, third and fifth ducts, a first intermediate point at the intersection of the first and third ducts , connecting here a chromatographic column connector, and a second intermediate point at the intersection of the second and fourth ducts, connecting here the connector of the other chromatographic column.
    [0022] The concepts of entry point, exit point and intermediate point mean that the respective ducts are directly connected together, that is, without any intermediate section or component.
    [0023] The bag is configured so that the liquid passes between the entry point and the exit point, when the first sections of the first and second ducts and the third and fourth ducts are pressed, and when the fifth duct is open.
    [0024] The bag is configured so that the liquid passes between the entry point and the first intermediate point, and then, between the second intermediate point and the exit point when the third, fourth and fifth ducts are pressed, and when the first sections of the first and second ducts are open.
    [0025] The bag is configured so that the liquid passes between the entry point and the second intermediate point, and then between the first intermediate point and the exit point, when the first sections of the first and second ducts and the fifth duct are pressed, and when the third and fourth ducts are open.
    [0026] In addition, the bag according to the invention is fully in accordance with the restrictions imposed on a two-dimensional circuit (which avoids the crossing of ducts), by means of the aforementioned arrangement of the first, second, third, fourth and fifth ducts.
    [0027] According to especially simple, convenient and economical characteristics of the bag according to the invention: - the bag comprises a sixth duct between a first feed pump connector and a waste container connector; - the bag comprises a seventh duct that extends from a bubble vent connector until it enters said sixth duct; - the bag comprises an eighth duct extending from a feed pump connector until it enters said seventh duct; - the bag comprises at least one ninth duct that extends between a bubble vent connector and an instrumentation connector; - the bag comprises at least one tenth duct which extends from a filter connector until it enters said ninth duct; and - the bag comprises an eleventh duct that extends between a bubble vent connector and an air connector; - said first end of said first section of said second duct is connected at least to a fraction container connector. - the bag comprises a twelfth duct which extends from a waste container connector until it enters said second duct; and - said second end of said first section of said first duct is connected to an instrumentation connector.
    [0028] According to a second aspect, the invention also relates to a device for an installation for the treatment of biological liquid by chromatography, comprising a circuit, the circuit of which consists of: - a bag provided with a number of connectors and a network for routing the liquid between said connectors, said routing network being formed by a number of ducts, the bag further comprising two flexible films connected with each other, said ducts being formed between said two flexible films; - a press comprising a first housing and a second housing mounted on said first housing, said first housing and second housing operate with said bag to form the ducts of said routing network between said flexible films, securing said bag between said first housing and said second housing; and - a number of valves;
    [0029] where a first duct with a first section having a first end and a second end which is an end opposite the first end is provided;
    [0030] where a second duct is provided with a first section having a first end and a second end which is an opposite end to the first end, the first section of the first duct and the first section of the second duct being opposite;
    [0031] where a third duct has a first end and a second end which is an opposite end to the first end, the third duct of which connects said respective first ends of said first respective sections of said first duct with said second duct, respectively, by its first end and its second end;
    [0032] where a fourth duct has a first end and a second end which is an opposite end to the first end, the fourth duct of which connects said respective second ends of said first respective sections of said first duct with said second duct, respectively, through its first end and its second end;
    [0033] where a fifth duct has a first end and a second end which is an end opposite the first end, said fifth duct connecting both, the second end of said first section of said first duct and said first end of said fourth duct by means of its first end, and said fifth duct connecting both, said first end of said first section of said second duct with said second end of said third duct through its second end;
    [0034] said first duct being connected to a chromatography column connector by said first end of its first section, and said second duct being connected to a chromatographic column connector by said second end of its first section; and
    [0035] where a first valve is placed on said first section of said first duct, a second valve is placed on said first section of said second duct, a third valve is placed on said third duct, a fourth valve is placed over said fourth duct, and a fifth valve is placed over said fifth duct.
    [0036] By virtue of the invention, the device for the treatment installation is especially convenient because it allows the chromatography treatment to be carried out (by opening and closing the valve on it, allowing or preventing the flow of liquid between the ducts) simply and with less space occupation.
    [0037] In addition, depending on the treatments to be performed, the biological liquid treatment installation comprises, in addition to the device according to the invention, by one or more different devices, for example, juxtaposed against the device according to the invention .
    [0038] This or these other devices are provided with the neighboring treatment components mentioned above formed especially by one or more pumps, for example, of the peristaltic type, and / or by a source container that contains the product to be treated and / or by a liquid collection container, by a chromatographic column, and by an instrumentation platform, these neighboring treatment components, each one being connected with the bag, directly or not.
    [0039] According to especially simple, convenient and economical characteristics of the device according to the invention: - the device comprises a sixth valve placed on said first duct between said first end of its first section and said chromatographic column connector ; - the device comprises a seventh valve placed on said second duct between said second end of its first section and said chromatographic column connector; - the bag comprises a sixth duct between a feed pump connector and a waste container connector, and the device comprises at least one eighth valve placed over said sixth duct; and - the bag comprises a seventh duct that extends from a bubble vent connector until it enters said sixth duct, and the device comprises a ninth valve placed over said seventh duct; the bag comprises an eighth duct extending from a feed pump connector until it enters said seventh duct, and the device comprises a tenth valve located on said eighth duct; - the bag comprises a ninth duct that extends between a bubble vent connector and an instrumentation connector, and the device comprises at least an eleventh valve placed over said ninth duct; - the bag comprises at least a tenth duct extending from a filter connector until it enters said ninth duct, and the device comprises at least a twelfth valve placed over said at least tenth duct; - the bag comprises an eleventh duct which extends between a bubble vent connector and an air connector, and the device comprises at least a thirteenth valve placed on said eleventh duct; - said first end of said first section of said second duct is connected to at least one fraction container connector, and the device comprises a fourteenth valve placed over said second duct; the bag comprises a twelfth duct which extends from a waste container connector until it enters said second duct, and the device comprises a fifteenth valve placed on said twelfth duct; and - the device comprises a pressure sensor placed on said ninth duct.
    [0040] The presentation of the invention will now be continued with the description of the achievements, presented below for purposes of illustrative and non-limiting example, with reference to the attached drawings, in which: - figure 1 is a perspective view of a device of the installation for the treatment of liquid by chromatography; figure 2 is a side view of the device; figure 3 is a rear view of a first device housing, with the rear panel removed; figures 4 and 5 are sectional views of the device, respectively, with an open valve and a closed valve; figure 6 is a front view of the first housing, on which a bag for the treatment of liquid by chromatography is mounted. figure 7 is a front view of the bag in isolation; and - figure 8 is a diagrammatic view of the circuit of an installation for the treatment of liquid by chromatography;
    [0041] Figures 1 and 2 illustrate a device 1 for an installation for the treatment of biological liquid by chromatography.
    [0042] Device 1 has a generally parallelepiped shape.
    [0043] This device 1 which comprises a base 2 having a first side face 3, a second side face 4 which is opposite the first side face 3, a front face 5 which meets the first and second side faces 3 and 4, and a rear face 6 which is opposite the front face 5 and which meets the first and second side faces 3 and 4.
    [0044] Device 1 further comprises a circuit 8 provided with a press 9 and a bag 10, which comprises a number of connectors 11 (11A to 11R in figures 6 and 7) for liquid and a network 12 for routing the liquid between these connectors 11 which include ducts 13 (13A to 13Q in figures 6 and 7), as will be seen in greater detail later.
    [0045] The press 9 comprises two housings 16 and 17 each one being formed by a solid block of rigid material.
    [0046] Here, housings 16 and 17 are made of polyoxymethylene (POM), also called acetal, and each of them having a generally parallelepiped shape.
    [0047] The housing 16 is mounted on the front face 5 of the base 2.
    [0048] The device 1 further comprises a door 20 hinged with the base 2.
    [0049] Frame 17 is mounted on that door 20.
    [0050] Device 1 has a closed door position in which door 20 is closed and covers housing 16 (figure 2), and another position in which bag 10 is supported only by housing 16 (figure 1).
    [0051] In this other position, housing 17 is far from housing 16.
    [0052] In the closed door position, bag 10 is embedded between the two housings 16 and 17.
    [0053] Device 1 is provided, at the bottom, with a closed receptacle 46 which is intended to receive one or more tanks, if necessary.
    [0054] This receptacle 46 is closed by a sliding panel 7 placed on the front face 5 of the device 1, whose panel 7 is adapted to be moved in translation downwards, and then in the rear direction of the device 1 (see the arrows in figure 1 ) for the insertion and removal of the tanks.
    [0055] A control panel 14 is placed on top of the front face 5 of device 1.
    [0056] This control panel 14 is provided with a graphic touch interface 15 that allows the biological liquid treatment process to be checked and controlled.
    [0057] This control panel 14 is then placed at a height that allows a user to use it.
    [0058] In order to make it easier to move, device 1 is in the form of a cart mounted on four wheels 18 (of which three of them can be seen in figure 1), with two wheels located under the front face of the device 5 comprising a lock 19, and with the device 1 in addition having two handles 21 on the respective opposite sides of the front face 5, close to the respective side faces 3 and 4.
    [0059] The device 1 comprises an inclined chassis 25 on its front face 5.
    [0060] On each of its left and right sides, the chassis 25 comprises two L-shaped claws 26 that emerge from their respective side and extend upwards.
    [0061] A support plate 27 is connected on the right side of the chassis 25 between the two support claws 26.
    [0062] This support plate 27 is placed in the immediate vicinity under the support claw 26 located higher on the right side, to allow free access to the support claw 26 located under the same right side.
    [0063] The support plate 27 comprises two fixation heads 28 in which a platform (not shown) is adapted to be installed to be placed in it the instruments for treating the biological liquid.
    [0064] These instruments, for example, may be optional sets, such as sensors for measuring pH or conductivity and are chosen by the user according to the type of treatment to be performed, as will be seen below, for treatment by chromatography.
    [0065] The base 2 of the device 1 further comprises devices 29, which, with the complementary devices 40 of the door 20, allow the installation and fixation of that door 20 in the closed door position.
    [0066] There are three of the devices 29 that are placed in the corners of the chassis 25, respectively on the upper right side, right side of the bottom, and left side of the bottom.
    [0067] These devices 29 each comprise a body, an annular shoulder (not shown), a head attached to that annular shoulder, that head having the shape of a conical tube and being provided internally with a rod 30 with a conical tip. The body comprises a pneumatic chamber, a piston that is mechanically connected to the rod 30 with a conical tip, the rod 30 of which is adapted to extend inside the head.
    [0068] Door 20 comprises a structure 35 having a generally rectangular arrangement.
    [0069] The structure 35 comprises four sides and three complementary devices 40 to operate with the devices 29 of the base 2, whose complementary devices 40 are placed, respectively, in the upper left, bottom left, and left corner of the right.
    These complementary devices 40 are provided with a first cylindrical portion and a second cylindrical portion that is hollow and is connected in the first portion by a shoulder. This second portion has a smaller diameter than the first portion.
    [0071] In addition, the second portion is provided with three openings on the outer surface.
    [0072] These complementary devices 40 further comprise three spheres (not shown) each of them being capable of being projected from the second portion, through the passage through a respective opening.
    [0073] In the closed door position, each second portion of a respective complementary device 40 of the door 20 is inserted in a respective head of a respective device 29 of the base 2.
    [0074] The devices 29 and the complementary devices 40 form, in pairs, the closing pin system with ball with the pneumatic lifting system of the double action type with a spring (not shown) having an extended position and a retracted position , the operation for which it is well known.
    [0075] The rod 30 of the device 29 is adapted to be inserted in the second hollow cylindrical portion when the lifting system is in its extended position.
    [0076] In this position of the lifting system, the rod 30 pushes the balls until each one passes through an opening, thus blocking the movement of the door 20 in relation to the base 2.
    [0077] The device 1 further comprises a hinge system through which the door 20 is connected by the hinge with the base 2.
    [0078] This hinge system is provided with a single hinge 42 comprising a first hinge portion 43 connected at the top right corner of the same structure 35 of door 20, and a second hinge portion (not shown) connected at the side face 3 base 2 of device 1.
    [0079] At the top of the second portion of the hinge, a mechanical spring (not shown) is placed with a plastic lock to facilitate opening and closing the door 20.
    [0080] The device also includes a position sensor (not shown) to check and provide security for opening and closing door 20, by detecting the closed door position and the other position.
    [0081] A pneumatic system (not shown) is also placed on top of the second portion of the hinge to provide a system (not shown) to close the housing 17, which is located on the door 20.
    [0082] In the closed door position, the axis of rotation around which the first portion of the hinge 43 of the door 20 rotates is counterbalanced in relation to a partition surface formed between the housings 16 and 17 when they secure the bag 10 between the same.
    [0083] This axial compensation towards the front of the device 1 allows lateral spaces to be formed between the door 20 and the base 2 in the external perimeter of the door 20 (figure 2).
    [0084] Therefore, access to connectors 11 of bag 10 is greatly facilitated.
    [0085] The housing 17 has a reference surface 80 which is flat here, and a number of format channels 81 recessed in that reference surface 80. This housing 17 has a first side 82 and a second side 83 which is a side opposite the first side 82, a third side 84 and a fourth side 85 which is a side opposite the third side 84, these third and fourth sides 84 and 85, each meeting the first and second sides 82 and 83.
    [0086] On its fourth side 85, the housing 17 is provided with two positioning holes 86 to position the bag 10, which are placed in front of the positioning openings 73 of the bag 10 in the closed door position, with the bag 10 stuck between housings 16 and 17.
    [0087] In addition, the housing 17 is provided with two other positioning holes 87 to position the door 20 in the closed door position, one of which is located on the first side 82 of the housing 17, and the other on the other end, at direction of the housing bottom 17.
    [0088] These two positioning holes 87 are placed so that they face the positioning openings 77 of the bag 20 in the closed door position, with the bag 10 secured between the housings 16 and 17.
    [0089] In a central zone, the housing 17 also comprises four closing holes 88 of a larger diameter than those two positioning holes 86 and 87 of that housing 17, whose closing holes 88 serve to close the housing 16 and 17 together.
    [0090] These four closing holes 88 are located in the places where there are most of the channels 81 that serve for the formation of the ducts 13, because it is in these places that the pressure force is the greatest during the treatment. The closing holes 88 are therefore at least partially surrounded by channels 81.
    [0091] These four closing holes 88 are placed so that they face the closing openings 75 of the bag 10 in the closed door position, with the bag 10 trapped between the housings 16 and 17.
    [0092] The housing 16 has a flat reference surface 95 and formatting channels 96 in recess in relation to the reference surface 95 (figure 4), each facing a corresponding formatting channel 81.
    [0093] Generally, surfaces 80 and 95 have similar dimensions and the arrangement of formatting channels 96 is the mirror image of the set of formatting channels 81.
    [0094] Formatting channels 81 and 96 are of semi-elliptical cross section.
    [0095] Surfaces 80 and 95 can be applied against each other with channels 81 and 96 corresponding to each other to delimit a network of cavities that generally each is tubular.
    [0096] Housing 16 has a first side 145 and a second side 146 which is opposite the first side 145, a third side 147 and a fourth side 148 which is opposite the third side 147, the third and fourth sides of which 147 and 148 each of them meets the first and second sides 145 and 146 (figure 6).
    [0097] The frame 16, moreover, has, on the opposite side walls 98 and 99, pins 100 adapted to be fitted, due to a vertical translation movement from the top to the bottom when the frame 16 is against the frame 25, on the support claws 26 placed on those chassis 25.
    [0098] Furthermore, on the same opposite side walls 98 and 99, the housing 16 has the rod 101 to handle the housing 16.
    [0099] This manipulation is performed by the user of device 1, with the help of a winch, which, for example, may be electric.
    [0100] Thanks to the inclination and weight of the housing 16, and thanks to the fitting of the pins 100 on the support claws 26, the housing 16 is securely attached to the chassis 20.
    [0101] On its flat reference surface 95, the housing 16, moreover, has a portion of recesses 102 which extends downwards through an inclined surface 103, the inclination of which is directed into the device 1.
    [0102] This inclined surface 103 provides access to the dam 46 which comprises the containers.
    [0103] On a bottom face 97, the housing 16 further comprises an inverted drip channel shape channel 104 that emerges on the inclined surface 103 (figure 1).
    [0104] This channel 104 serves as a mistake-proof device in the installation of the housing 16 on the chassis 25 of the base 2, so that the reference surface 95 is turned outwards.
    [0105] The housing 16 further comprises, on its fourth side 148, by two fixing pins 106 which are spaced evenly.
    [0106] These tacks 106 are adapted to pass through the positioning openings 73 of the bag 10 for the suspension of the last one over the housing 16.
    [0107] In addition, the furthest end of these same tacks 106 is adapted to be inserted into the positioning holes 86 of the housing 17 in the closed door position.
    [0108] The housing 16 comprises two positioning pins 107 for positioning the door 20, one of which is located on the fourth side 148 of the housing 16 next to a fastener 106 located on the left at the top of that housing 16, the other positioning 107 being located at the other end, that is, at the bottom of the housing 16, between two format channels 96 at the location of the third side 147.
    [0109] These positioning tacks 107 are adapted to pass through the openings 77 of the bag 10, and the distant end of these positioning tacks 107 is adapted to be inserted into the positioning holes 87 of the housing 17.
    [0110] The housing 16 also comprises four fixing holes 108 which are located in the places where most of the channels 96 exist, which serve for the formation of the ducts 13, because it is in these places that the pressure force is greatest during the treatment. The fixing holes 108 are therefore at least partially surrounded by channels 96.
    [0111] These fixing holes 108 are placed so that they face the penetration openings 75 of the bag 10 when it is placed on the housing 16, and also to face the corresponding fixing holes 88 of the housing 17 in the closed door position.
    [0112] The fixing holes 108 of the housing 16 are passed through the ball closing pins 110 to jointly close the housing 16 and 17 when the door 20 is in its closed position, and for fixing the bag 10 in the circuit 8.
    [0113] Each locking pin with ball 110 comprises a body connected to the housing 16, an annular shoulder provided with a transverse face and connected to a head (which are not shown). The body comprises a pneumatic chamber and a piston, the piston being mechanically connected with a rod with a conical tip (not shown). This rod extends to the head of the pin 110 and three balls 119 (figure 6) are placed in such a way that they are capable of being projected from the head by passing through the openings formed in that head. Pin 110 is similar to a double action type lifting system and has an extended and a retracted position.
    [0114] The head of each pin 110 passes through the fixing hole of the housing 16, this head also passing through the corresponding fixing opening 75 of the bag, and this head finally emerges in a corresponding fixing hole 88 of the housing 17 in its closed door position.
    [0115] When a first portion of the pin 110 pneumatic chamber is placed under pressure, the piston is actuated. When the piston is at the end of the displacement, the balls 119 are in the extended position, that is, they protrude from the head to extend into the fixing hole 88 of the housing 17.
    [0116] The fixing holes 88 are configured in such a way that when the balls 119 are extended, the housings 16 and 17 are fixed firmly.
    [0117] When a second portion of the pin 110 pneumatic chamber is placed under pressure, this second portion being opposite the first portion, the piston is driven in the direction of the other end of the displacement position. When that position is reached, the spheres 119 are in the retracted position, that is, they return to the head.
    [0118] In addition to frames 16 and 17, device 1 comprises, installed here at the rear of frame 16, the instruments required for the treatment of the biological liquid illustrated in figure 3.
    [0119] Compression valves 125 A to 125 W (figure 3) are illustrated, comprising actuators 221 (figures 4 and 5) to compress the corresponding duct 13 to prevent or allow the passage of liquid in that duct 13, and a sensor of pressure 126.
    [0120] A pneumatic distributor 128 and means for checking and controlling the execution of various treatments of that liquid are also illustrated, which means that they are formed, for example, by a checking and control unit 127.
    [0121] In the example illustrated in figures 4 and 5, actuators 221 each comprise a body 223 connected with housing 16 and a movable compression finger 224 having a stowed position when valve 125 is in the open position and an extended position when valve 125 is in the closed position.
    [0122] The body 223 comprises a pneumatic chamber 226, a piston 227 and an accommodation 228 provided with a spring 229 accommodated in the housing, with the spring 229 surrounding a rod connecting the piston 227 to the finger 224.
    [0123] The pneumatic chamber 226, when under pressure, compresses piston 227 against spring 229. When piston 227 is at the end of its travel, finger 224 is in the retracted position (figure 4).
    [0124] When the pneumatic chamber 226 is at atmospheric pressure, spring 229 compresses piston 227 in the direction of the other position of the end of its displacement. When the latter is reached, the movable finger 224 is in the extended position (figure 5).
    [0125] At its far end, the movable finger 224 is formatted as the profile of the formatting channel 81 of the housing 17.
    [0126] In the extended position, the movable finger 224 is projected into one of the channels 81.
    [0127] The valve 125 further comprises, according to the movable finger 224, a plastically compressible paddle 231 whose paddle 231 forms a part of an individual local silicone plate 230 molded in one piece (see also figure 1).
    [0128] This blade 231 has a first face 232 next to the movable finger 224 and a second face 233 next to the duct to compress the 13.
    [0129] The second face 233 of blade 231 is concave and delimits the formatting channel 96 of frame 16 locally.
    [0130] Each actuator 221 allows a duct 13 to be compressed between the movable finger 224 and the housing 17, to allow or prevent the passage of liquid in that location.
    [0131] To compress duct 13, valve 125 moves from its open position (figure 4) in which the movable finger 224 is in the stowed position in which it does not compress duct 13, to its closed position (figure 5) in which the movable finger 224 is in the extended position in which it compresses the duct 13.
    [0132] Finger 224, which at that moment is extended, pushes blade 231 in the direction of formatting channel 81 of housing 17.
    [0133] Therefore, the blade 231 changes from a resting configuration in which its second face 233 is concave and delimits locally the formatting channel 96 of the housing 16 of the duct 13 to compress, until a compressed configuration in which its second face 233 is convex, with duct 13 and blade 231 as a sandwich between the formatting channel 81 of housing 17 of duct 13 for compression and the movable compression finger 224.
    [0134] In addition, sensor 126 is connected with housing 16 according to channel 96, with the furthest end of sensor 126 emerging on that channel 96, without actually having to come in contact with the fluid (not shown) .
    [0135] Such a pressure sensor measures the pressure across the outer surface of the bag 10.
    [0136] The housing 16 also includes, installed here behind that housing 16, a female connector 130 that allows power to be supplied to the 125A-125W valves, the sensor 126, the distributor 128 and the verification and control unit 127, which are integrated into that frame 16 (figure 3).
    [0137] The supply is electric (for power and control) and pneumatic.
    [0138] This female connector 130 is placed on the right side of the bottom of the housing 16 (seen from behind).
    [0139] When the rear of the housing 16 is covered by a bottom panel, only access to the female connector 130 is possible.
    [0140] A male connector (not shown) placed on the base 2 of the device 1 can be connected with the female connector 130 of the circuit 8.
    [0141] The bag 10 comprises two flexible films 65 and 66 connected with each other by a seal that delimits a closed contour (figures 4 and 7), and the connectors 11 of the routing network 12.
    [0142] Therefore, each of the 65 and 66 films is a PureFlex® film from the applicant.
    [0143] This is a coextruded film comprising four layers, respectively, from the inner side to the outer side, a layer of ultra low density polyethylene (ULDPE) forming the material for contact with a liquid, a copolymer of ethylene and vinyl alcohol ( EVOH) which forms a gas barrier, a layer of ethylene and vinyl acetate copolymer (EVA) and a layer of ultra low density polyethylene (ULDPE) forming the outer layers.
    [0144] The seal is a weld bead formed on the periphery of films 65 and 66 at the location of ducts 13.
    [0145] Ducts 13 (13A to 13Q in figures 6 and 7) are formed in the passage of a liquid.
    [0146] The closed contour of the bag 10 forms a liquid treatment zone, in which the ducts 13 extend.
    [0147] The closed contour has a first side 68, a second side 69 that is opposite the first 68, a third side 70 that meets the first and second sides 68 and 69 and a fourth side 71 that is an opposite side to the third side 70 and that meets the first and second sides 68 and 69. The connectors 11A to 11P of the routing network 12 emerge in and out of the first, second, and third sides 68, 69 and 70, as can be seen more especially in figure 7.
    [0148] The dimensions of the bag 10 correspond to those of the surfaces of the carcasses 16 and 17.
    [0149] The bag 10 is provided to be fixed between the carcasses 16 and 17 with one side of the bag 10 in contact with the face of the carcass 16, and with the other face of the bag 10 being in contact with the face of the carcass 17 .
    [0150] On its fourth side 71, the bag 10 comprises two penetration openings 73 for its fixation, as mentioned above.
    [0151] These positioning openings 73 are aligned and spaced evenly and serve to position the bag 10 in the housing 16.
    [0152] The bag 10 further comprises, in its treatment zone 67, four penetration openings 75 referred to above to fix the carcasses 16 and 17 together, these fixation openings 75 having a larger diameter than the positioning openings 73.
    [0153] These positioning openings 75 are located in the treatment zone in the places where most of the ducts exist 13, because it is in these places that the pressure force is the greatest during the treatment. The fixing openings 75 are therefore at least partially surrounded by the ducts 13.
    [0154] The bag 10 further comprises two positioning openings 77 referred to above which serve to position the door 20 in the closed door position of the device.
    [0155] One of the positioning openings 77 is placed on the fourth side 71 of the bag 10 in the vicinity of the positioning opening 73 located at the top left of the bag 10, and the other positioning opening 77 is located at the opposite end, that is, towards the bottom of the bag 10, in the treatment zone.
    [0156] A more detailed description of ducts 13A to 13B and connectors 11A to 11R of bag 10 will now be presented, as well as valves 125A to 125W and sensor 126 that are integrated in frame 16 and the components of the neighborhoods that operate in together with ducts 13A to 13Q and their connectors 11A to 11R, with references to figures 6 and 7.
    [0157] The neighborhood treatment components are made up of peristaltic pumps, various containers and other measuring instruments, as will be seen below.
    [0158] These neighborhood treatment components are represented in a diagram here and are connected in the bag 10 which is mounted on the housing 16 (figure 6) or only in the bag 10 (figure 7), but in reality, these components are placed in one or more different devices, for example, placed against device 1.
    [0159] These other devices are advantageously trolleys like device 1.
    [0160] It is clear that the connections that will be described below can be formed before fixing the bag 10 by suspension in the housing 16, without it being damaged later, that is, when fixing that bag 10 in the housing 16 by the hinge system , or after the suspension of that bag 10.
    [0161] On its first side 68, bag 10 comprises a connector 11A connected to a duct 13A which extends almost horizontally (with a slight inclination of approximately 2 to 3 degrees) as a first section starting from connector 11A until it is reached a folded section, extending vertically to the third side 70 of bag 10, where that duct 13A is connected to a connector 11B.
    [0162] Connector 11A is connected to a feed pump 414 and connector 11B is connected to a waste container 400.
    [0163] A 404 flow meter is placed between the feed pump and the 11A connector.
    [0164] This feed pump 414 may be connected to a source container 417 (with a product detector 415 placed between that source container 417 and that feed pump 414), a container for the kidney fluid 418, a container for cleaning liquid 419, a container for buffer liquid 420 and the container for elution product 421.
    [0165] On its first side 68, above connector 11A, bag 10 also comprises a connector 11D connected to a duct 13D that extends on that connector 11D as a first horizontal section, and then as a second section forming a first branch Y, and then over a third section forming a second branch of that Y, until it enters duct 13A.
    [0166] The 11D connector is connected to a 402 bubble vent.
    [0167] The bag 10 also comprises, on its first side 68, between connector 11D and connector 11A, a connector 11C connected to a duct 13C that extends from connector 11C until it enters the third section of duct 13D.
    [0168] Connector 11C is connected to a feed pump 413.
    [0169] A 403 flow meter is placed between the feed pump 413 and the connector 11C.
    [0170] This feed pump 413 itself can be connected to five containers, each containing a buffer solution 422 to 426.
    [0171] The bag 10 also comprises on its first side 68, well above the connector 11D, a connector 11E connected to a duct 13E that extends from that connector 11E to the connector 11H located on the second side 69 of the bag 10.
    [0172] Connector 11E is connected to bubble bleed 402 and connector 11H is connected to an instrumentation platform 405, which consists of a conductivity sensor, a temperature sensor, a bubble detector and a pH sensor.
    [0173] Bag 10 comprises a 13G duct that extends from a junction between the second section and the third section of the 13D duct until it enters the 13E duct in such a way that this 13G duct forms the third branch of the Y.
    [0174] This 13G duct allows the purging of bubbles 402 to be avoided.
    [0175] Bag 10 also comprises, on its first side 68, above connector 11E, two other connectors 11G and 11F both connected in a 13F U-shaped duct.
    [0176] The 11G connector is connected to the bubble bleed 402 and the 11F connector is opened to the atmosphere (a tube with a free end is connected to it).
    [0177] On its third side 70, bag 10 comprises a connector 11I connected to a duct 13 HI that extends from that connector 11I until it enters duct 13E at another junction.
    [0178] This 11I connector is connected to a 401 filter for the treatment of the liquid.
    [0179] On the same side 70, bag 10 further comprises a connector 11J connected to a duct 13I that extends from that connector 11 J until it enters duct 13E at another junction.
    [0180] This 11J connector is also connected with a 401 filter to treat the liquid.
    [0181] The bag 10 comprises, on its second side 69, above the connector 11H, a connector 11K connected in another duct 13J that extends from that connector 11K to another connector 11L located on the same side 69 of the bag 10, at its end top (at the top right corner of bag 10).
    [0182] The 11K connector is connected with the 405 instrumentation platform and the 11L connector is connected with a 406 chromatographic column.
    [0183] Above this 11K connector is a 11M connector connected to a 13K duct that extends from that 11M connector to another 11N connector located on the same side 69 of bag 10, just below the 11L connector.
    [0184] Connector 11M is connected with chromatographic column 406 and connector 11N is connected to a collection container 407, referred to as fraction 1.
    [0185] On that same side 69, above connector 11M, bag 10 is still composed of a connector 11R connected to a duct 13B that extends from that connector 11R as a first horizontal section, and then upwards, as a second vertical section until entering the 13K duct.
    [0186] That connector 11R is connected to a waste container 412.
    [0187] Still on that same side 69, between connectors 11N and 11R, bag 10 is still composed of three connectors 11O, 11P and 11Q respectively, connected in ducts 13O, 13P and 13Q, each extending from the respective connector 11O, 11P and 11Q until entering duct 13B.
    [0188] Connectors 11O, 11P and 11Q are connected, respectively, to the collection containers 408 (for fraction 2), 410 (for fraction 3), and 411 (for fraction 4).
    [0189] A filter 409 is placed between connector 11O and the collection container 408 for fraction 2, because it is usually in that container 408 that the desired treated liquid is collected.
    [0190] Duct 13J extends from connector 11K as a first almost horizontal section (with a slightly positive curve between side 69 and side 68), and then as a second section 13 J1 oriented almost diagonally in relation to bag 10, and then as a second section 13 J1 oriented almost diagonally with respect to bag 10, and then as a third section that extends vertically upwards towards the top of bag 10 and finally as a fourth section returning towards the second side 69 of bag 10 with an orientation that is substantially horizontal (with a slight positive slope between side 68 and side 69).
    [0191] With respect to the 13K duct, it extends from the 11M connector as a very short first horizontally oriented section and then as a second 13K1 section oriented substantially in parallel with the second 13J1 section of the 13J duct, and then after a folded section , the 13K duct continues as a third section directed to the second side 69 of the bag with a positive slope between the first side 68 and the second side 69, and finally this 13K duct continues as a fourth substantially horizontal section until reaching the 11N connector.
    [0192] Three other 13L, 13M and 13N ducts detailed below are placed over the respective second sections 13J1 and 13K1 of the 13J and 13K ducts.
    [0193] Duct 13L, oriented perpendicular to sections 13J1 and 13K1, has a first end 13L1 and a second end 13L2 which is an end opposite the first end 13L1, with the first end 13L1 of that duct 13L meeting a first end 13J2 of section 13J1 of duct 13J, and with the second end 13L2 of duct 13L meeting a first end 13K2 of section 13K1 of duct 13K.
    [0194] Duct 13M, oriented perpendicular to two sections 13J1 and 13K1, has a first end 13 M1 and a second end 13M2 which is an end opposite the first end 13M1, with the first end 13M1 of duct 13M meeting a second end 13J2 which is an end opposite the first end 13J2 of section 13J1 of duct 13J, and the second end 13M2 of duct 13M meeting a second end 13K3 which is an end opposite the first end 13K2 of section 13K1 of duct 13K.
    [0195] Duct 13 N, vertically oriented in relation to bag 10, has a first end 13 N1 and a second end 13N2 which is an opposite end to the first end 13N1, with the first end 13N1 meeting a second end 13J3 of section 13J1 of duct 13J and the first end 13M1 of duct 13M, and the second end 13N2 of duct 13N meeting the first end 13K2 of section 13K1 of duct 13K and the second end 13L2 of duct 13L.
    [0196] Housing 16 comprises a valve 125A and an elastic regulator 231A on the first section of the duct 13A, as well as a valve 125B and an elastic regulator 231 on the second (vertical) section of the duct 13A, the intersection between the duct 13A and the 13D pipeline being located between those two valves 125A and 125B.
    [0197] Housing 16 further comprises a valve 125C and an elastic regulator 231D over duct 13D, at the location of the first branch Y.
    [0198] Frame 16 comprises a 125G valve and an elastic regulator 231G over duct 13G, at the location of the second branch of the Y.
    [0199] On duct 13E, housing 16 also comprises a valve 125E of a 231E elastic regulator placed before the intersection between the 13G and 13E duct, as well as a 125H valve and a 231H elastic regulator placed just after the intersection between duct 13G and duct 13E, and a 125I valve and an elastic regulator 231 placed just after the intersection between duct 13H and duct 13E and just before the intersection between duct 13I and duct 13E.
    [0200] Frame 16 also includes a pressure sensor 126 over that duct 13E, just after the intersection between duct 13E and duct 13I.
    [0201] On the 13H duct, the housing 16 also includes a 125J valve and an elastic regulator 231J.
    [0202] Frame 16 also comprises a 125K valve and an elastic regulator 231K over the 13G duct.
    [0203] The housing 16 also comprises a 125F valve and an elastic regulator 231F over the 13F duct.
    [0204] On its second side 146, frame 16 comprises a 125W valve and an elastic regulator 231W over duct 13K, close to connector 11N.
    [0205] Frame 16 also comprises a 125S valve and an elastic regulator 231S over duct 130.
    [0206] The housing comprises a 125T valve and an elastic regulator 231T over the 13P duct.
    [0207] Housing 16 comprises a 125U valve and an elastic regulator 231U over the 13Q duct.
    [0208] Frame 16 also includes a 125V valve and an elastic regulator 231V over duct 13B, close to connector 11R.
    [0209] The housing 16 also comprises, substantially in its center, a 125L valve and an elastic regulator 231L over section 13J1 of duct 13J, between the two ends 13J2 and 13J3, and a 125M valve and an elastic regulator 231M over that same duct 13J just after the 13J2 end of section 13J1.
    [0210] On the 13K duct, the housing 16 also comprises a 125N valve and an elastic regulator 231N on its section 13K1, between its two ends 13K2 and 13K3, and a valve 125 and an elastic regulator 231O placed between the end 13K3 and the 11M connector.
    [0211] The housing 16 also includes a 125P valve and an elastic regulator 231P over the 13 L. duct.
    [0212] Frame 16 also comprises a 125R valve and an elastic regulator 231R over the 13M duct.
    [0213] Finally, frame 16 comprises a 125Q valve and an elastic regulator 231 Q over the 13 N. duct.
    [0214] Each connector 11A to 11R has a section in semi-elliptical section and is provided with a longitudinal duct 90 in which two annular walls 91 and 92 are formed which define, between them, an annular channel 93, the annular wall 91 being juxtaposed against the films 65 and 66 of the bag 10 and the annular wall 92 being offset with respect to those films 65 and 66 towards the end of the tube 90 to which a tube is connected for its connection to a component in the vicinity.
    [0215] Each connector 11A to 11R is further provided with a ring 94 mounted around channel 93 for sealing the corresponding connector in relation to films 65 and 66 of bag 10.
    [0216] A more detailed description of the circuit for the treatment of liquid by chromatography will now be made, with reference to figure 8, with the components in the vicinity.
    [0217] Figure 8 diagrammatically shows circuit 8 provided by press 9 and bag 10. In this circuit, valves 125A to 125W are formed respectively by an actuator 221, and by the portion of the housing 17 against which the duct 13 presses when it is pressed by the finger 224.
    [0218] The liquid to be treated is initially in a 417 source bag filled with liquid from the bioreactor or from the previous treatment. This source bag 417 is connectable with a female connector 617 that is connected to the feed pump 414. Between that female connector 617 and that pump 414 a product detector 415 is installed as well as a valve 717. At the outlet of the pump 414 it is also a 404 flow meter is installed.
    [0219] The respective containers for the rinsing liquid 418, the cleaning liquid 419, the buffer liquid 420 and the elution separator product 421 can be connected in that duct 13A through a male connector, respectively, 518, 519, 520, 521. These respective male connectors are connectable with corresponding female connectors 618, 619, 620 and 621, which are connected with the feed pump 414 through the respective valves 718, 719, 720 and 721.
    [0220] The sections formed between the various containers and that feed pump are formed by disposable flexible ducts.
    [0221] The feed pump 414 (here a peristaltic pump) as well as the respective valves 717 to 721 allows the liquid to be made to flow into the duct 13A.
    [0222] The term "duct" should be understood in the current document as being a portion of pipe that connects two elements of the circuit, being possible that this portion, likewise, comprises a single pipe or on the contrary, several pipes, possibly having different diameters, connected in series via a simple connector (having no other function here) or a sophisticated connector (for example, a disposable connector for a pressure sensor (or for a sensor of other physical-chemical value)).
    [0223] The 125A valve is implanted in the duct 13A near the connector 11A to allow or prevent the flow of liquid in the duct.
    [0224] Other products of buffer solution are present in the respective containers 422 to 426, which are connectable, respectively, through a male connector 522 to 526, to the duct 13C.
    [0225] For this purpose, the respective male connectors 522 to 526 are connected to the respective female connectors 622 to 626, which can be connected with the feed pump 413 through the respective valves 722 to 726.
    [0226] A 403 flow meter is placed between the feed pump 413 and the duct 13C.
    [0227] The 125C valve is placed in the duct 13C next to the 11C connector to allow or prevent the flow of liquid in the duct.
    [0228] The liquid to be treated is usually a mixture of the product from the source bag with products of buffer solution, and this mixture is produced through feed pumps 413 and 414, as well as through valves 125C to 125A .
    [0229] The product detector 415 makes it possible to detect whether the liquid is passing through the duct 13a and, if applicable, whether the targeted liquid is being sent directly, through the 125A valve opening and the opening from valve 125B, to a waste container 400. For this purpose, the waste container 400 is connected via a male connector 500 to a female connector 11B.
    [0230] The bubble vent 402 can be connected to duct 13E through male connectors 502 and 602 which are connectable with female connectors 11D and 11E.
    [0231] The 125D and 125E valves allow the bubble bleed 402 to be filled or not.
    [0232] The bubble drain 402 further comprises an additional valve 702.
    [0233] Filter 401 can be connected to duct 13E through male connectors 501 and 601 which are connectable, respectively, with female connectors 11I and 11J.
    [0234] The 125J and 125K valves allow the liquid to pass or prevent it from passing through that 401 filter.
    [0235] The 125G, 125 and 125I valves allow the purging of bubbles 402 and the filter 401 to be avoided, with valves 125D, 125E, 125J and 125 K being closed.
    [0236] Pressure sensor 126 is implanted in duct 13E.
    [0237] Chromatographic column 406 is connectable with duct 13J and with duct 13K through male connectors 506 and 606, which are connectable with the respective female connectors 11L and 11M.
    [0238] The 125L, 125M, 125P, 125N, 125R and 125O valves allow the liquid flow to be created in the 406 chromatographic column.
    [0239] The 125Q valve allows the 406 chromatographic column to be avoided.
    [0240] Device 1 comprises an instrumentation platform 430 comprising especially a conductivity sensor, a temperature sensor, a pH sensor and a UV sensor, this platform being placed in front of the 407, 408, 410 and 411.
    [0241] These collection containers 407, 408, 410 and 411, as well as the waste container 412, can be connected to the 13K duct, respectively, through a female connector 507, 508, 510, 511 and 512, which can be connected with the male connector 11N, 11O, 11P, 11Q and 11R.
    [0242] The 125W, 125S, 125T, 125U and 125V valves allow the liquid flow to the respective collection containers and the 412 waste container to be used or not used.
    [0243] A filter 409 is placed between the female connector 508 and the collection container 408, in which fraction 2 of the treated liquid, which is desired, is recovered.
    [0244] The operation of this circuit will now be described.
    [0245] Valves 717, 125C, 125G, 125H, 125I, 125Q and 125V are opened to allow the flow of the product from the source into the circuit, the other valves being closed.
    [0246] In this case, the liquid seeps into the 13C pipeline, then the 13G, and then the 13E, and then the 13J, and then it passes through the 13N pipeline until it reaches the junction between that 13N pipeline and the 13K pipeline, and then it passes through duct 13K until duct 13B is reached, where the product is collected in the waste container 412.
    [0247] Next, the container 420 for the buffer liquid is switched on, whose buffer liquid passes through the bubble purge 402, into the filter 401, and then into the chromatographic column 406 until it is collected in the container reject 412.
    [0248] For this purpose, the valves 720, 125C, 125D, 702, 125E, 125H, 125J, 125K, 125L, 125M, 125O, 125N and 125V are opened, the other valves being closed.
    [0249] The buffer liquid then passes into tubes 13A, 13D, 13E, and 13J (including section 13 J1), until chromatographic column 406 is reached (passing through instrumentation platform 405). The buffer liquid exits that column 406 and flows into duct 13K (including section 13K1) until it reaches duct 13B to be collected in the waste container 412.
    [0250] The treatment cycle for the source product from container 417 proceeds with the following, whose product passes into filter 401 and then into chromatographic column 406, and is collected in waste container 412.
    [0251] For this purpose, valves 717, 125C, 125G, 125H, 125J, 125K, 125L, 125M, 125O, 125N and 125V are opened, the other valves being closed.
    [0252] Therefore, the liquid from the source passes into the ducts 800, 13C, 13D, 13E, 13H, 13I and 13J (through section 13 J1) until it finds the chromatographic column 406. The liquid leaves that column 406 through the 13K duct (and section 13K1) and then passes to the waste container 412 through duct 13B.
    [0253] As soon as the source liquid is placed in chromatographic column 406, it is processed in a cleaning cycle, the container containing cleaning liquid 419 being connected, the liquid of which passes through the bubble purge 402, the filter 401, the instrumentation platform 405 and the chromatographic column 406 until collected in the waste container 412.
    [0254] For this purpose, valves 119, 125C, 125D, 125E, 125H, 125J, 125K, 125L, 125M, 125N, 125O and 125V are open, the other valves being closed.
    [0255] Therefore, the cleaning liquid passes inside the ducts 13C, 13D, 13E, 13H, 13I and 13J (including section 3J1) until and enters the chromatographic column 406. The cleaning liquid leaves that column 406 and passes through from duct 13K (including section 13K1) until it reaches the waste container 412 through duct 13B.
    [0256] Next, an elution cycle (first elution step) is carried out in which the elution separator product present in container 421 passes through the bubble purge 402, filter 401 and chromatographic column 406 until it is collected in the container 407 for fraction 1.
    [0257] For this purpose, the container 421 containing the elution separator product is connected, and the valves 721, 125C, 125D, 125E, 125H, 125J, 125K, 125L, 125M, 125O, 125N, and 125 W are opened, the other valves being closed.
    [0258] Therefore, the product of the elution separator passes inside the ducts 13C, 13D, 13E, 13H, 13I, and 13J (including section 13 J1) until reaching the 406 chromatographic column.
    [0259] The liquid leaves this column 406 and passes through the duct 13K until it reaches the container 407 of fraction 1.
    [0260] Next, the elution (second step) is continued, in which a mixture of the product and the elution separator from container 421 and at least one buffer solution product from containers 422 to 426 passes in the direction of bag 10.
    [0261] For this purpose, the referred containers are connected and the mixing is done by means of pumps 413 and 414.
    [0262] Valves 721, 722 and / or 723 and / or 724 and / or 725 and / or 726, and valves 125C and 125, valves 125D, 125E, 125H, 125J, 125K, 125L, 125M, 125O, 125N and 125S are opened, the other valves being closed.
    [0263] Therefore, the mixture obtained passes through the bleed of bubbles 402, filter 401, instrumentation platform 405 and then the chromatographic column 406 until it is collected in container 408 for fraction 2. The treated liquid also passes through the interior of filter 409.
    [0264] The liquid from the feed pump 413 passes through the duct 13C and the liquid or liquids from the feed pump 414 pass into the duct 13A until the liquid reaches the duct 13D where the mixing then takes place. The mixture continues to pass through pipeline 13E and then into pipeline 13J (including section 13J1) and then into the chromatographic column 406, from which it leaves and passes through pipeline 13K (including section 13K1) until it reaches container 408 for fraction 2 through the 13O duct.
    [0265] Other steps may be performed with respect to this fraction 2 of the collected product, such as pH adjustment.
    [0266] To finish, in a cycle of regeneration of the chromatographic column 406, a specific product of buffer solution from one of the containers 422 to 426 passes inside the bubble purge 402 to the filter 401 and to the chromatographic column 406, from the bottom, until collected in the 412 waste container.
    [0267] For this purpose, one of the containers 422 to 426 is connected and one of the valves 722 to 726 as well as the valves 125A, 125C, 125D, 125E, 125H, 125J, 125K, 125R, 125O, 125M, 125D, 125P, and 125V are opened, the other valves being closed.
    [0268] This regeneration liquid therefore passes into duct 13A, and then into duct 13D, and then into duct 13E, and then into duct 13J, and then into duct 13M (the liquid does not passes into tube 13J1), and then into duct 13K and then chromatographic column 406 is reached (the liquid does not pass into the chromatographic column from the top) in connector 11M, and then passes into duct 13J until it reaches the 13J2 end of section 13J1, and then passes into duct 13L, and then into duct 13K (the liquid does not pass into sections 13J1 and 13K1) until it reaches the waste container 412 through duct 13B.
    [0269] For each step described above, it is possible to avoid the bubble bubbler 402 by closing the 125G valves and opening the 125D, 125E and 125F valves to make the liquid pass through the 13G duct.
    [0270] In addition, it is also possible to avoid the 401 filter by closing the 125I valves and closing the 125J and 125K valves (the liquid does not flow into the 13H and 13I ducts).
    [0271] In a non-illustrated variant, the pumps are of the diaphragm type instead of peristaltic.
    [0272] In a non-illustrated variant, the 405 instrumentation platform is integrated in housing 16. Connectors 11H and 11K are therefore absent, and ducts 13E and 13J are directly reached.
    [0273] In a non-illustrated variant, the dimensions of the bag 10 do not match those of the surfaces of the carcasses 16 and 17, being larger or smaller.
    [0274] In another variant not shown, the installation does not include a chromatographic column but on the contrary, it has an ion exchange column or an adsorption membrane.
    [0275] It should be noted more generally that the invention is not limited to the described and represented examples.
    权利要求:
    Claims (22)
    [0001]
    1. Bag for a circuit of an installation for the treatment of a biological liquid by chromatography, characterized by the fact that it comprises: - a number of connectors (11A-11R) and a routing network (12) to route the liquid between those referred to connectors (11A-11R), said routing network (12) being formed by a number of ducts (13A-13Q); and - two flexible films (65, 66) connected with each other, said ducts (13A-13Q) being formed between the two said flexible films (65, 66); where a first duct (13J) is provided with a first section (13J1), which has a first end (13J2) and a second end (13J3) which is an end opposite the first end (13J1); where a second duct (13K) is provided with a first section (13K1), which has a first end (13K2) and a second end (13K3) which is an end opposite the first end (13K2), the first section (13J1) the first duct (13J) and the first section (13K1) of the second duct (13K) being opposite; and where a third duct (13L) has a first end (13L1) and a second end (13L2) which is an end opposite the first end (13L1), whose third duct (13L) connects said first ends (13J2, 13K2) said first sections (13J1, 13K1) of said first duct (13J) and said second duct (13K) respectively by their first ends (13L1) and their second ends (13L2); where a fourth duct (13M) has a first end (13M1) and a second end (13M2) which is an opposite end to the first end (13M1), whose fourth duct (13M) connects said respective second ends (13J3, 13K3) said respective first sections (13J1, 13K1) of said first duct (13J) and said second duct (13K), respectively, by its first end (13M1) and its second end (13M2); where a fifth duct (13N) has a first end (13N1) and a second end (13N2) which is an end opposite the first end (13N1), said fifth duct (13N) connecting both, the second end (13J3) of said first section (13J1) of said first duct (13J) and said first end (13M1) of said fourth duct (13M) by its first end (13N1) and said fifth duct (13N) connecting both, said first end (13K2) of said first section (13K1) of said second duct (13K) and said second end (13L2) of said third duct (13L) by its second end (13N2); and said first duct (13J) being connected to a chromatographic column connector (11L) by said first end (13J2) of its first section (13J1), and said second duct (13K) being connected to a chromatographic column connector (11M) through said second end (13K3) of its first section (13K1); where the bag is configured in such a way that the liquid to be treated passes into said chromatographic column through one of said first (13J) and second (13K) ducts, and the liquid to be treated can avoid said chromatographic column by passing into the fifth duct (13N).
    [0002]
    2. Bag according to claim 1, characterized by the fact that it comprises a sixth duct (13A) between a feed pump connector (11A) and a waste container connector (11B).
    [0003]
    3. Bag according to claim 2, characterized by the fact that it comprises a seventh duct (13D) that extends from a bubble bubbler connector (11S) until it enters said sixth duct (13A).
    [0004]
    4. Bag according to claim 3, characterized by the fact that it comprises an eighth duct (13C) that extends from a feed pump connector (11C) until it enters said seventh duct (13D).
    [0005]
    5. Bag according to any of claims 1 to 4, characterized by the fact that it comprises at least a ninth duct (13E) that extends between a bubble bubbler connector (11E) and an instrumentation connector (11H).
    [0006]
    6. Bag according to claim 5, characterized by the fact that it comprises at least one tenth duct (13H, 13I) that extends from a filter connector (11I, 11J) until entering the said ninth duct (13E) .
    [0007]
    7. Bag according to any one of claims 1 to 6, characterized in that it comprises an eleventh duct (13F) that extends between a bubble bubbler connector (11G) and an air connector (11F).
    [0008]
    8. Bag according to any of claims 1 to 7, characterized in that said first end (13K2) of said first section (13K1) of said second duct (13K) is connected at least to a fraction container connector ( 11N-Q).
    [0009]
    9. Bag according to claim 8, characterized by the fact that it comprises a twelfth duct (13B) that extends from a waste container connector (11R) until it enters said second duct (13K).
    [0010]
    10. Bag according to any of claims 1 to 9, characterized in that said second end (13J3) of said first section (13J1) of said first duct (13J) is connected to an instrumentation connector (11K).
    [0011]
    11. Device for an installation for the treatment of biological liquid by chromatography, characterized by the fact that it comprises a circuit (8) composed of: - a bag (10) supplied with a number of connectors (11A-11R) and a network ( 12) for routing the liquid between said connectors (11A-11R), said routing network (12) being formed by a number of ducts (13A-13Q), the bag (10) further comprising two flexible films (65 , 66) connected with each other, said ducts (13A-13Q) being formed between said two flexible films (65, 66); - press (9) comprising a first housing (16) and a second housing (17) mounted on said first housing (16), said first housing (16) and the second housing (17) cooperating with said bag (10 ) to form the ducts (13A-13B) of said routing network (12) between said flexible films (65, 66), securing said bag (10) between said first housing (16) and said second housing ( 17); and - a number of valves (125A-W); where a first duct (13J) is provided with a first section (13J1), which has a first end (13J2) and a second end (13J3) which is an end opposite the first end (13J1); where a second duct (13K) is provided with a first section (13K1), which has a first end (13K2) and a second end (13K3) which is an end opposite the first end (13K2), the first section (13J1) the first duct (13J) and the first section (13K1) of the second duct (13K) being opposite; and where a third duct (13L) has a first end (13L1) and a second end (13L2) which is an end opposite the first end (13L1), whose third duct (13L) connects said respective first ends (13J2, 13K2 ) of said respective first sections (13J1, 13K1) of said first duct (13J) and said second duct (13K) respectively by its first end (13L1) and its second end (13L2); where a fourth duct (13M) has a first end (13M1) and a second end (13M2) which is an opposite end to the first end (13M1), whose fourth duct (13M) connects said respective second ends (13J3, 13K3) said respective first sections (13J1, 13K1) of said first duct (13J) and said second duct (13K), respectively, by its first end (13M1) and its second end (13M2); where a fifth duct (13N) has a first end (13N1) and a second end (13N2) which is an end opposite the first end (13N1), said fifth duct (13N) connecting both, the second end (13J3) of said first section (13J1) of said first duct (13J) and said first end (13M1) of said fourth duct (13M) by its first end (13N1) and said fifth duct (13N) connecting both said first end ( 13K2) of said first section (13K1) of said second duct (13K) and said second end (13L2) of said third duct (13L) by its second end (13N2); and said first duct (13J) being connected to a chromatographic column connector (11L) by said first end (13J2) of its first section (13J1), and said second duct (13K) being connected to a chromatographic column connector (11M) through said second end (13K3) of its first section (13K1); and where a first valve (125L) is placed over said first section (13J1) of said first duct (13J), a second valve (125N) is placed over said first section (13K1) of said second duct (13K), a third valve (125P) is placed over said third duct (13L), a fourth valve (125R) is placed over said fourth duct (13M), and a fifth valve (125Q) is placed over said fifth duct (13N) ).
    [0012]
    Device according to claim 11, characterized in that it comprises a sixth valve (125M) placed on said first duct (13J) between said first end (13J2) of its first section (13J1) and said connector chromatographic column (11L).
    [0013]
    13. Device according to one of claims 11 and 12, characterized in that it comprises a seventh valve (125O) placed over said second duct (13k) between said second end (13K3) of its first section (13K1) and said chromatographic column connector (11M).
    [0014]
    Device according to any of claims 11 to 13, characterized in that the bag (10) comprises a sixth duct (13A) between a feed pump connector (11A) and a waste container connector (11B), and the device comprises at least one eighth valve (125A, 125B) placed over said sixth duct (13A).
    [0015]
    15. Device according to claim 14, characterized in that said bag (10) comprises a seventh duct (13D) extending from a bubble bubbler connector (11D) until it enters said sixth duct (13A), and the device comprises a ninth valve (125D) placed over said seventh duct (13D).
    [0016]
    16. Device according to claim 15, characterized in that said bag (10) comprises an eighth duct (13C) extending from a feed pump connector (11C) until it enters said seventh duct (13D), and the device comprises a tenth valve (125C) placed over said eighth duct (13C).
    [0017]
    17. Device according to any of claims 11 to 13, characterized in that said bag (10) comprises a ninth duct (13E) that extends between a bubble bubbler connector (11E) and an instrumentation connector (11H ), and the device comprises at least an eleventh valve (125E, 125H, 125I) located over said ninth duct (13E).
    [0018]
    18. Device according to claim 17, characterized in that said bag (10) comprises at least one tenth duct (13H, 13I) extending from a filter connector (11I, 11J) until it enters said ninth duct (13E), and the device comprises at least a twelfth valve (125J, 125K) placed over at least one twelfth duct (13H, 13I).
    [0019]
    19. Device according to any of claims 11 to 18, characterized in that said bag (10) comprises an eleventh duct (13F) extending between a bubble bubbler connector (11G) and an air connector ( 11F), and the device comprises at least a thirteenth valve (125F) placed over said eleventh duct (13F).
    [0020]
    20. Device according to any of claims 11 to 19, characterized in that said first end (13K2) of said first section (13K1) of said second duct (13K) is connected to at least one fraction container connector ( 11N-Q), and the device comprises a fourteenth valve (125W) placed over said second duct (13K).
    [0021]
    21. Device according to claim 10, characterized in that said bag (10) comprises a twelfth duct (13B) extending from a waste container connector (11R) until it enters said second duct (13K) ), and the device comprises a fifteenth valve (125V) placed over said twelfth duct (13B).
    [0022]
    22. The device according to any of claims 11 to 21, characterized in that it comprises a pressure sensor (126) placed on said ninth duct (13E).
    类似技术:
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    同族专利:
    公开号 | 公开日
    US20120145616A1|2012-06-14|
    WO2012001569A1|2012-01-05|
    CN102946960A|2013-02-27|
    ES2575854T3|2016-07-01|
    BR112012030481A2|2019-06-25|
    US9174145B2|2015-11-03|
    CN102946960B|2014-09-24|
    KR101442433B1|2014-09-17|
    SG185753A1|2013-01-30|
    JP2013534822A|2013-09-09|
    JP5758487B2|2015-08-05|
    EP2585187B1|2016-04-20|
    EP2585187A1|2013-05-01|
    FR2961711B1|2012-08-17|
    KR20130031353A|2013-03-28|
    FR2961711A1|2011-12-30|
    引用文献:
    公开号 | 申请日 | 公开日 | 申请人 | 专利标题
    US2413853A|1942-03-18|1947-01-07|Metalwash Machinery Co|Article washing machine|
    US2787403A|1953-09-01|1957-04-02|Fmc Corp|Pumping apparatus|
    US2941575A|1955-09-14|1960-06-21|Paul R Malmberg|Apparatus for dielectric fabrication|
    US3022229A|1957-04-01|1962-02-20|Getinge Mek Verkst S Aktiebola|Cultivation plant|
    US3179117A|1964-03-02|1965-04-20|Cart Cleaning Corp Of America|Trailer mounted cleaner|
    US3667487A|1970-12-11|1972-06-06|Richardson Chem Cleaning Servi|Integrated chemical cleaning apparatus|
    US3774762A|1971-01-20|1973-11-27|E Lichtenstein|Analogue fluid flow programming structures|
    US4370983A|1971-01-20|1983-02-01|Lichtenstein Eric Stefan|Computer-control medical care system|
    US3772154A|1971-05-03|1973-11-13|Technicon Instr|Method and apparatus for automated antibiotic susceptibility analysis of bacteria samples|
    GB1434786A|1973-04-02|1976-05-05|Lichtenstein E S|Apparatus including disposable array for processing body fluids|
    FR2241615B3|1973-08-22|1976-07-30|Aseta|
    US4113623A|1977-04-25|1978-09-12|Food Automation-Service Techniques, Inc.|Filter apparatus|
    US4161264A|1977-06-17|1979-07-17|Johnson Bryan E|Fluid metering and mixing device having inlet and outlet valves|
    US4332750A|1980-03-11|1982-06-01|Essex Chemical Corporation|Blow-molding and degating hollow shapes|
    US5141866A|1983-07-26|1992-08-25|Robert Levin|Process for plant tissue culture propagation|
    IL69333A|1983-07-26|1986-04-29|Biolog Ind|Process for plant tissue culture propagation|
    JPH049456B2|1985-10-07|1992-02-20|
    US4915119A|1986-04-21|1990-04-10|Dober Chemical Corporation|Cleaning apparatus and method|
    US4784751A|1986-09-24|1988-11-15|Keller Machine Works|Method and apparatus for reclaiming contaminated oil|
    US4790118A|1987-04-13|1988-12-13|Econodose, Inc.|Medication packaging and dispensing system|
    JPS63319011A|1987-06-19|1988-12-27|Takano:Kk|Parallel filtration circuit|
    US4852851A|1987-12-11|1989-08-01|Integrated Fluidics, Inc.|Valve with flexible sheet member|
    JPH0583251B2|1990-10-02|1993-11-25|Daiichi Kogyo Kk|
    FR2673853B1|1991-03-12|1993-07-16|Leflond Odile|UNDERWATER ROTATING MIXER REACTOR, PARTICULARLY FOR THE ANAEROBIC FERMENTATION OF HUMIDIFIED HOUSEHOLD GARBAGE.|
    IT1251639B|1991-10-28|1995-05-17|Sviluppo Settori Impiego Srl|PROCEDURE FOR THE PRODUCTION OF MANUFACTURES STARTING FROM REINFORCED THERMOPLASTIC SHEETS|
    US5290518A|1992-08-17|1994-03-01|Eastman Kodak Company|Flexible extraction device with burstable sidewall|
    US5678568A|1993-07-27|1997-10-21|Olympus Optical Co., Ltd.|System control apparatus, medical system control apparatus and image-plane display method of medical system control apparatus|
    US5265912A|1992-10-19|1993-11-30|Natividad Jeffrey A|Toy train apparatus|
    US5520885A|1993-01-19|1996-05-28|Thermogenesis Corporation|Fibrinogen processing apparatus, method and container|
    DK0643591T3|1993-03-03|1999-06-07|Deka Products Lp|Peritoneal Dialysis Systems and Methods Using a Liquid Distribution and Pump Cartridge with Independent Air Insulation and Bo|
    WO1996012952A1|1994-10-20|1996-05-02|Eai Corporation|Air transportable, modular analytical laboratory|
    US5985653A|1995-06-07|1999-11-16|Aastrom Biosciences, Inc.|Incubator apparatus for use in a system for maintaining and growing biological cells|
    JP2832586B2|1995-08-04|1998-12-09|株式会社トミー精工|DNA extraction and purification method|
    FR2747780B1|1996-04-22|1998-06-05|Cogema|DEVICE FOR TAKING HARMFUL LIQUID SAMPLES, ESPECIALLY LOADED WITH SOLID PARTICLES|
    US5738645A|1996-04-30|1998-04-14|Medtronic, Inc.|Soft tip blood reservoir for heart-lung machines|
    US6808675B1|1996-06-25|2004-10-26|Thermogenesis Corp.|Freezing and thawing bag, mold, apparatus and method|
    US6146124A|1996-06-25|2000-11-14|Thermogenesis Corp.|Freezing and thawing bag, mold, apparatus and method|
    US6213334B1|1996-09-05|2001-04-10|Baxter International Inc|Flexible, three-dimensional containers and methods for making them|
    US6073942A|1996-11-14|2000-06-13|Windquest Companies, Inc.|Movable dual cart assembly|
    US6129099A|1997-09-17|2000-10-10|Foster; James B.|Pallet washing apparatus and method|
    US6361642B1|1997-12-02|2002-03-26|Baxter International Inc.|Heat and pressure-formed flexible containers|
    JPH11169432A|1997-12-09|1999-06-29|Hosokawa Yoko:Kk|Infusion bag and its production|
    EP2316570A3|1998-05-01|2011-07-27|Gen-Probe Incorporated|Automated diagnostic analyzer and method|
    US6099734A|1998-07-08|2000-08-08|Baxter International Inc.|Apparatus, membranes and methods for removing organic compounds from a biological fluid|
    US6228255B1|1998-07-24|2001-05-08|Dialysis Systems, Inc.|Portable water treatment facility|
    US8505959B2|2000-09-18|2013-08-13|Valiant Rock, Llc|Cart transportable mobile medical critical care point of need field installation units|
    US20040222341A1|1999-01-27|2004-11-11|Health Science Technology, LLC|Intravenous equipment hangers|
    EP1154827B1|1999-02-22|2006-10-11|NCSRT, Inc.|Purification of biological substances|
    FR2795476B1|1999-06-22|2001-07-27|Biomerieux Sa|VALVE FOR DIRECTING A FLUID IN AN ANALYSIS CARD|
    EP2290050B1|1999-09-08|2012-06-13|Levitronix Technologies, LLC|Bioreactor|
    US6303025B1|2000-02-17|2001-10-16|Jon E. Houchens|Water purification system with baffled flow|
    EP1195171B1|2000-10-04|2012-08-15|Terumo Kabushiki Kaisha|Peritoneal dialysis apparatus|
    US6582386B2|2001-03-06|2003-06-24|Baxter International Inc.|Multi-purpose, automated blood and fluid processing systems and methods|
    EP1239277A1|2001-03-09|2002-09-11|Infineon Technologies AG|Measurement arrangement|
    US6982063B2|2001-05-25|2006-01-03|Matrix Technologies Corp|Automated pipetting system|
    US6673595B2|2001-08-27|2004-01-06|Biocrystal, Ltd|Automated cell management system for growth and manipulation of cultured cells|
    US20040031507A1|2002-05-09|2004-02-19|Advanced Blending Corp.|Systems and method for automated cart washing|
    US7153286B2|2002-05-24|2006-12-26|Baxter International Inc.|Automated dialysis system|
    DE10224750A1|2002-06-04|2003-12-24|Fresenius Medical Care De Gmbh|Device for the treatment of a medical fluid|
    DE60325850D1|2002-06-13|2009-03-05|Graco Minnesota Inc|STRUCTURAL SPRAYER WITH ADJUSTABLE FLOW AND TUBING PUMP|
    US9283521B2|2002-06-14|2016-03-15|Parker-Hannifin Corporation|Single-use manifold and sensors for automated, aseptic transfer of solutions in bioprocessing applications|
    US7238164B2|2002-07-19|2007-07-03|Baxter International Inc.|Systems, methods and apparatuses for pumping cassette-based therapies|
    US7073765B2|2002-11-13|2006-07-11|Hill-Rom Services, Inc.|Apparatus for carrying medical equipment|
    US20040104153A1|2002-11-29|2004-06-03|Chung-Hsiang Yang|Portable water purifier|
    US20040259240A1|2003-06-17|2004-12-23|Fadden Stephen J.|Method and apparatus for filtration of bioreactor recombinant proteins|
    EP1508791A1|2003-08-22|2005-02-23|Ismatec SA, Laboratoriumstechnik|Device for automated bioreactor sampling|
    US8038639B2|2004-11-04|2011-10-18|Baxter International Inc.|Medical fluid system with flexible sheeting disposable unit|
    US7198052B2|2004-03-12|2007-04-03|General Electric Company|Mobile flushing unit and process|
    WO2005090403A2|2004-03-12|2005-09-29|Biovest International, Inc.|Method and apparatus for antibody purification|
    EP1732744B1|2004-03-30|2015-09-02|Hosokawa Yoko Co., Ltd.|Method and apparatus for producing bag with mouth member|
    US7326355B2|2004-03-31|2008-02-05|Hyclone Laboratories, Inc.|Mobile filtration facility and methods of use|
    US20060024212A1|2004-08-02|2006-02-02|Hwang David S|Analytical equipment cart|
    KR100618320B1|2004-09-14|2006-08-31|삼성전자주식회사|An apparatus for making a fluid flow, and a disposable chip having the same|
    AU2005296352B2|2004-10-21|2011-01-06|Cytiva Bioprocess R&D Ab|Chromatography ligand|
    US20060195064A1|2005-02-28|2006-08-31|Fresenius Medical Care Holdings, Inc.|Portable apparatus for peritoneal dialysis therapy|
    US7935074B2|2005-02-28|2011-05-03|Fresenius Medical Care Holdings, Inc.|Cassette system for peritoneal dialysis machine|
    WO2007052718A1|2005-11-01|2007-05-10|Medinet Co., Ltd.|Shaker for cell culture and shaken culture system in cell culture method|
    WO2007094254A1|2006-02-15|2007-08-23|Aida Engineering, Ltd.|Microchannel chip and method for manufacturing such chip|
    US20070199875A1|2006-02-28|2007-08-30|Moorey Ian M|Portable water purification system|
    US7485224B2|2006-03-03|2009-02-03|Sam Houston State University|Mobile bioremediation systems|
    DE102006018824A1|2006-04-22|2007-10-25|Bayer Technology Services Gmbh|Disposable bioreactor|
    WO2007139747A1|2006-05-22|2007-12-06|Biovest International Inc.|Interface of a cultureware module in a cell culture system and installation method thereof|
    JP4721227B2|2006-05-22|2011-07-13|アイダエンジニアリング株式会社|Microchannel chip and manufacturing method thereof|
    US8545636B2|2006-07-27|2013-10-01|Atmel Corporation|Conductivity control of water content in solvent strip baths|
    US20080116122A1|2006-11-22|2008-05-22|Genitope Corporation|Chromatography systems comprising single-use components|
    DE102006059459B4|2006-12-14|2009-06-18|Boehringer Ingelheim Microparts Gmbh|Device for receiving or manipulating a liquid and method for producing such a device|
    AU2007331761B2|2006-12-14|2013-06-13|Boehringer Ingelheim Microparts Gmbh|Device for the intake or manipulation of a liquid|
    JP4957260B2|2007-01-16|2012-06-20|横河電機株式会社|Chemical reaction cartridge and method of use thereof|
    GB0706240D0|2007-03-30|2007-05-09|Concept 2 Manufacture Design O|A valve means for gas control devices|
    CN101765448A|2007-08-02|2010-06-30|米利波尔公司|System and apparatus for processing fluid samples|
    US7798456B2|2007-08-21|2010-09-21|Hill-Rom Services, Inc.|Transferable patient care equipment support|
    US8105487B2|2007-09-25|2012-01-31|Fresenius Medical Care Holdings, Inc.|Manifolds for use in conducting dialysis|
    CA2945389C|2007-10-04|2018-11-20|Dornoch Medical Systems, Inc.|Medical waste fluid collection and disposal system|
    WO2009046989A2|2007-10-11|2009-04-16|Roche Diagnostics Gmbh|Carrier for an infusion system|
    US8114276B2|2007-10-24|2012-02-14|Baxter International Inc.|Personal hemodialysis system|
    US9415150B2|2007-11-09|2016-08-16|Baxter Healthcare S.A.|Balanced flow dialysis machine|
    US8114288B2|2007-11-29|2012-02-14|Fresenlus Medical Care Holdings, Inc.|System and method for conducting hemodialysis and hemofiltration|
    US8075468B2|2008-02-27|2011-12-13|Fenwal, Inc.|Systems and methods for mid-processing calculation of blood composition|
    FR2931838B1|2008-06-02|2010-06-11|Millipore Corp|INSTALLATION FOR TREATING A BIOLOGICAL LIQUID.|
    US7892496B2|2008-06-20|2011-02-22|Silverbrook Research Pty Ltd|Mechanically-actuated microfluidic pinch valve|
    EP2297571B1|2008-06-25|2017-10-11|GE Healthcare Bio-Sciences Corp.|An automated installation procedure for a disposable flow path|
    CN101393184B|2008-10-30|2011-06-22|中国烟草总公司郑州烟草研究院|Analytical method of heterocyclic amine compound in cigarette mainstream flue gas|
    FR2940145B1|2008-12-24|2011-03-25|Millipore Corp|TROLLEY AND INSTALLATION FOR TREATING A BIOLOGICAL LIQUID|
    DE102009005874A1|2009-01-21|2010-07-22|Thinxxs Microtechnology Ag|Valve, in particular for a component of microfluid technology|
    FR2941385B1|2009-01-23|2011-04-01|Millipore Corp|METHOD FOR PROVIDING A CIRCUIT FOR BIOLOGICAL LIQUID AND CIRCUIT OBTAINED|
    AU2010210385A1|2009-02-06|2011-08-18|Velomedix, Inc.|Method and apparatus for inducing therapeutic hypothermia|
    DE102009009728A1|2009-02-19|2010-09-02|Thinxxs Microtechnology Ag|Flow cell with integrated fluid storage|
    FR2943134B1|2009-03-13|2011-10-07|Millipore Corp|DEVICE FOR DETERMINING A PHYSICAL SIZE OF A LIQUID CIRCULATING IN A CONDUIT|
    FR2955119B1|2010-01-13|2012-12-28|Millipore Corp|CIRCUIT FOR BIOLOGICAL LIQUID|
    WO2011130865A2|2010-04-21|2011-10-27|Yves Larcher|Automated cell culture system|
    FR2960794B1|2010-06-08|2012-07-27|Millipore Corp|DEVICE FOR A PLANT FOR TREATING BIOLOGICAL LIQUID|
    FR2960795B1|2010-06-08|2012-07-27|Millipore Corp|DEVICE FOR A PLANT FOR TREATING BIOLOGICAL LIQUID|
    FR2960796B1|2010-06-08|2014-01-24|Millipore Corp|DEVICE FOR A PLANT FOR TREATING BIOLOGICAL LIQUID|
    FR2961713B1|2010-06-23|2012-08-10|Millipore Corp|POCKET FOR CIRCUIT OF A BIOLOGICAL LIQUID TREATMENT FACILITY|
    FR2963573B1|2010-08-03|2012-08-31|Millipore Corp|PUMPING TROLLEY FOR A BIOLOGICAL LIQUID TREATMENT FACILITY|
    FR2973396B1|2011-03-28|2013-05-10|Millipore Corp|FACILITY FOR TREATING BIOLOGICAL LIQUID|FR2931838B1|2008-06-02|2010-06-11|Millipore Corp|INSTALLATION FOR TREATING A BIOLOGICAL LIQUID.|
    FR2940145B1|2008-12-24|2011-03-25|Millipore Corp|TROLLEY AND INSTALLATION FOR TREATING A BIOLOGICAL LIQUID|
    FR2941385B1|2009-01-23|2011-04-01|Millipore Corp|METHOD FOR PROVIDING A CIRCUIT FOR BIOLOGICAL LIQUID AND CIRCUIT OBTAINED|
    FR2955119B1|2010-01-13|2012-12-28|Millipore Corp|CIRCUIT FOR BIOLOGICAL LIQUID|
    FR2960794B1|2010-06-08|2012-07-27|Millipore Corp|DEVICE FOR A PLANT FOR TREATING BIOLOGICAL LIQUID|
    FR2960796B1|2010-06-08|2014-01-24|Millipore Corp|DEVICE FOR A PLANT FOR TREATING BIOLOGICAL LIQUID|
    FR2960795B1|2010-06-08|2012-07-27|Millipore Corp|DEVICE FOR A PLANT FOR TREATING BIOLOGICAL LIQUID|
    FR2961713B1|2010-06-23|2012-08-10|Millipore Corp|POCKET FOR CIRCUIT OF A BIOLOGICAL LIQUID TREATMENT FACILITY|
    FR2963573B1|2010-08-03|2012-08-31|Millipore Corp|PUMPING TROLLEY FOR A BIOLOGICAL LIQUID TREATMENT FACILITY|
    FR2973396B1|2011-03-28|2013-05-10|Millipore Corp|FACILITY FOR TREATING BIOLOGICAL LIQUID|
    FR2993572B1|2012-07-23|2016-04-15|Emd Millipore Corp|CIRCUIT FOR BIOLOGICAL LIQUID COMPRISING A PINCH VALVE|
    FR2993473B1|2012-07-23|2014-08-29|Emd Millipore Corp|DEVICE FOR A PLANT FOR TREATING BIOLOGICAL LIQUID|
    US20150133861A1|2013-11-11|2015-05-14|Kevin P. McLennan|Thermal management system and method for medical devices|
    AU2014364913B2|2013-12-16|2019-07-04|Icu Medical, Inc.|Door mount stabilization system for an infusion pump|
    US10143795B2|2014-08-18|2018-12-04|Icu Medical, Inc.|Intravenous pole integrated power, control, and communication system and method for an infusion pump|
    EP3304373B1|2015-05-26|2020-07-08|ICU Medical, Inc.|Disposable infusion fluid delivery device for programmable large volume drug delivery|
    EP3950042A1|2015-09-15|2022-02-09|Repligen Corporation|Flexible tubing management system for pharmaceutical, bioprocess applications, and food/dairy applications|
    US10406252B2|2017-01-19|2019-09-10|Curium Us Llc|Systems and methods for autoclave cart loading and unloading system|
    EP3381529A1|2017-03-29|2018-10-03|EMD Millipore Corporation|Facility for treating a biological fluid|
    EP3381530A1|2017-03-29|2018-10-03|EMD Millipore Corporation|Facility for treating a biological fluid|
    EP3599275A1|2018-07-27|2020-01-29|EMD Millipore Corporation|Facility for treating a biological fluid|
    USD939079S1|2019-08-22|2021-12-21|Icu Medical, Inc.|Infusion pump|
    法律状态:
    2019-07-09| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|
    2019-08-27| B25G| Requested change of headquarter approved|Owner name: EMD MILLIPORE CORPORATION (US) |
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    2020-12-29| B16A| Patent or certificate of addition of invention granted|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 20/06/2011, OBSERVADAS AS CONDICOES LEGAIS. |
    优先权:
    申请号 | 申请日 | 专利标题
    FR1055026|2010-06-23|
    FR1055026A|FR2961711B1|2010-06-23|2010-06-23|POCKET FOR CIRCUIT OF A BIOLOGICAL LIQUID TREATMENT FACILITY|
    PCT/IB2011/052679|WO2012001569A1|2010-06-23|2011-06-20|A bag for a circuit of a biological liquid treatment installation|
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